Controlled release matrix tablets with HPMC KLV, HPMC K4M, HPMC K15M, and HPMC KM were formulated by wet (non-aqueous) granulation method. Surface plots of log viscosity with temperature (°C) and HPMC concentration (%, w/w) for HPMC a K LV, b K4M, c K15M and d KM. Download/Embed scientific diagram | Swelling index of HPMC K4M at different concentrations from publication: Influence of different grades and concentrations .

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The comparison of different grades of HPMC at different concentration and temperature would also be more tedious and time-consuming. The release rate from matrix systems remains unaffected by thin spots, pinholes, and other similar defects, which can be a serious problem with reservoir systems 2.

Product Development, Pharmaceutics International, Inc.

Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M

Excipient Toxicity and Safety. Dickinson E, Eriksson L. Even though these techniques are useful for extracting information from the different viscosity profiles, it may be increasingly complex and time-consuming when many formulations are involved and the plots overlap with one another.

The aim of the present investigation was to develop oral controlled release matrix tablet formulations of isoniazid using hydroxypropyl methylcellulose HPMC as a hydrophilic release retardant polymer and to study the influence of various formulation factors like proportion of the polymer, polymer viscosity grade, compression force, and release media on the in vitro release characteristics of the drug.

The Einstein coefficient depends on the geometry and orientation of the entities that make up the dispersed phase, e. Ashland makes their documentation available in the regions indicated below: In the later hours also, the release rates remained similar, as initial porosity has no effect on the release from the swollen tablet matrix. This showed that addition of MNZ, despite in the same amount in all formulations, increased the melt suspension viscosities to different extents.


Thus, from present studies, it was observed that the humidity was one of the most important parameters that affected the stability of isoniazid in all polymer formulations.


Although polymers have been studied over the years, polymer rheology is a difficult subject to comprehend 1. The batch reproducibility study indicated that the formulation methodology employed IPA granulation was found to be suitable for manufacturing good quality CR matrix tablets of isoniazid. Open in a separate window. Within this time, major amount of the drug might have been released. Company Ashland is a developer and manufacturer of stabilizers and gums used in the Food, Beverage, and Nutrition industry.

Hence, at the same concentration, KM particles were numerically larger in number, resulting in greater retardation to flow. Multivariate methods in pharmaceutical applications.

Hypromellose – Wikipedia

This results in subtherapeutic concentrations of the drug in the blood, which leads to treatment failure and also encourages the isoniazid resistant strains of Mycobacterium tuberculosis.

Matrix technologies have often proven popular among the oral controlled drug delivery technologies because of their simplicity, ease in manufacturing, high level of reproducibility, stability of the raw materials and dosage form, and ease of scale-up and process validation.

Thus, the present study aimed at the design of isoniazid CR formulations by using relatively simple manufacturing technology which can be easily adopted in industrial units on a commercial scale. Prentice Hall Professional Technical Reference; Other research groups have reported similar k4 that the drug release rate k44m with increasing molecular weight for low-molecular-weight HPMCs and became independent of molecular weight for high-molecular-weight HPMCs 29 — An increase in particle size and size distribution favoured particle-particle interaction, which in turn increased viscosity.


Many pharmaceutical processes such as hot melt extrusion 2 — 5 and spray congealing 6 — 8 and hhpmc such upmc solid dispersions 910suppositories 11 and pessaries utilize polymer melts. J Phys Chem Solids. Metronidazole MNZ was included as the model drug, as most pharmaceutical formulations contain at least one active pharmaceutical ingredient.

Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M by Ashland – Food, Beverage & Nutrition

A total of 44 ternary formulations hpmv 20 binary formulations were prepared. Particle size and size distribution of HPMC played an important role in the viscosity of melt suspensions.

Reactivity of dissolving pulp: Smaller particles led ypmc a greater viscosity than larger particles. Please review our privacy policy. However, molar substitution is also often expressed in percentages. Like gluten, HPMC can trap air bubbles formed by the yeast in bread dough, causing the bread to rise.

Similarly, the drug release was observed to be higher in 0.

This product is widely used in food applications such as batters, hpm, extruded and fried foods, bakery fillings and toppings, meat and meat substitutes, soups, sauces, ice cream, and more. Batch Reproducibility The tablets showed low standard deviation values for the drug content, friability, weight variation, and hardness from three different batches prepared separately data not shown.

Because hypromellose solution is a non-newtonian solution and exhibits pseudoplastic, more specifically, thixotropic behavior, various test methods are available, and the results of different methods and viscosmeters do not necessarily correspond to each other.

The particle shapes of the different HPMC grades were l4m to be variable, albeit generally elongated Fig. Please review our privacy policy.